Hyperosmolal vaginal lubricants markedly reduce epithelial barrier properties in a three-dimensional vaginal epithelium model

Translation: some lubricants can damage the skin barrier, increasing the risk for sexually transmitted diseases. Right?

OP should probably simplify the title.

I understood some of those words

So Hawk Tuah is better than lube?

We just use baby oil or, more commonly, coconut oil. Coconut oil is so juicy and lubey and stays lubed for a long time, even when exposed to air. One tablespoon is enough for a very large area as well. 😏🍑

Something about vagina..

Cool study, ty

Abstract

Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and significantly increase vaginal transmission of genital herpes infections in the mouse/HSV model. They also cause toxicity to explants of vaginal epithelia, to cultured vaginal epithelial cells, and increase susceptibility to HIV in target cells in cell cultures. Here, we report that the osmolality of healthy vaginal fluid is 370 ± 40 mOsm/Kg in women with Nugent scores 0–3, and that a well-characterized three-dimensional human vaginal epithelium tissue model demonstrated that vaginal lubricants with osmolality greater than 4 times that of vaginal fluid (>1500 mOsm/Kg) markedly reduce epithelial barrier properties and showed damage in tissue structure. Four out of four such lubricants caused disruption in the parabasal and basal layers of cells as observed by histological analysis and reduced barrier integrity as measured by trans-epithelial electrical resistance (TEER). No epithelial damage to these layers was observed for hypo- and iso-osmolal lubricants with osmolality of <400 mOsm/Kg. The results confirm extensive reports of safety concerns of hyperosmolal lubricants and suggest the usefulness of reconstructed in vitro vaginal tissue models for assessing safety of lubricants in the absence of direct clinical tests in humans.

Interesting. As women tend to combat vaginal dryness later in life, guidelines like these are especially needed there. Pretty sure you very easily fall into a vicious circle of lubing, ruining cells which produce any remaining lube -> lubing even more. I guess the bottom line is to buy water-based lubes with some sort of an organic "gel" source and avoid propylene glycol/tons of glycerine/detergets (though those are harder to detect by name).

I highly recommend Sliquid for a lubricant. We have tried many others, and none compare.

https://sliquid.com/shop/sliquid-naturals/h2o-sliquid-naturals/

^ This is the water based, which is nice for those that prefer it

https://sliquid.com/shop/sliquid-naturals/silk-sliquid-naturals/

^ This is the hybrid lubricant, our holy grail. It has a little silicone in it, which keeps it from drying out and getting gummy, while still feeling natural and not leaving us with a greasy clean up.

The Sliquid Silk hybrid lube was also tested and is silicone toy safe. We have personally tested it with every toy we have, including Bad Dragon soft and medium, leaving it on the test pucks for a few days with no change in the material.

Also here is a lovely list of lubes tested for ph and osmolality:

https://phallophilereviews.com/ph-balanced-lubricant-guide-safety/

Link is broken for me

Here for the hawk tua comments