How have you given two week notices in the past?

So, I've given several two week notices throughout my career. Unfortunately, I recently had to give one over the phone instead of in person. I only report to one guy and he was on vacation. I could have just given it to HR but that would have felt scummy. I called him and gave him my notice then sent him a letter of resignation. Feels bad man. Anyone else ever have to give a two week notice in an awkward/unfortunate way?