On the computer thread, changing the keys on their keyboard is also fun. Works better if they are a touch typist as well, as they may go several hours/days before noticing, until they have to look for that one special key. :)
If we're talking computers, screenshot their desktop, set it as background, move taskbar to top, auto hide it, right-click desktop and choose hide icons.
Advanced mode: also set screen flip to 180 degrees and flip the background so it looks right side up.
Follow it up by placing a tiny bit of clear soft plastic in with the laser. It doesn't stop the mouse from working, but if you were you draw a straight line the cursor wobbles slightly.