Personal ones. If I had to distill it here, I require that my prose be varied but sensible (e.g. breaks the rules for readability, never egregiously), with no formula, no waffle words, and no meaningless sentences. Tropes can be fine but only used sparingly, naturally, and absolutely not always in the same place. Reading level should be collegiate, but not doctoral, and industry terms should be defined on first use. These are stylistic questions shaped by years of reading professional authors and no AI has any idea how to do that out of the box. Reading what most people put out with AI, I can see the patterns like repeating textures, and it grates on my optic nerves.
I'm making progress on that with mine, but it's a tough problem. Needs manual tweaking even after multiple rounds of automated revision.
The sentiment is true - my employer is heavily adopting AI in our processes and we haven't fired anyone, nor are we going to. We don't have the numbers to lose, and everyone who's using AI in their role wants to, because it's improving our output.
But this article was written by AI and prompted by someone who didn't try to improve its writing. Therefore I'm not interested in reading it. Why would I read a slop article from someone else, rather than having my own assistant compile a better one?
Misleading headline. What they actually demonstrated is reversing amyloid accumulation and the cognitive deficits in a transgenic mouse whose pathology is essentially just amyloid accumulation. Calling that "reversing Alzheimer's" treats amyloid buildup and the disease as the same thing, which is exactly the conflation the amyloid hypothesis has been criticised for over the last decade.
Alzheimer's in humans is amyloid + tau tangles + neuroinflammation + vascular dysfunction + actual neurodegeneration (entorhinal and hippocampal neurons dying, brain volume measurably dropping on MRI). Tau burden correlates with cognitive decline far better than amyloid does. The IBEC paper addresses one of those layers, the upstream-ish one, in a model that doesn't reproduce most of the others. Fixing a cause in a young system before damage has accumulated is just not the same operation as fixing an established disease in an old human cortex that's already lost the cells.
The human translation data backs this up. Lecanemab clears plaques and slows cognitive decline by about 27% over 18 months. Donanemab clears around 76% of plaques and slows decline by ~35% in early AD. In both trials both arms still declined, treatment just declined a bit more slowly. Northwestern's Mesulam Institute puts it bluntly: "These medications do not reverse existing disease or stop the progression." So removing amyloid in a system that already has the full human pathology bends the curve, it doesn't undo anything.
What the IBEC team has here is a genuinely interesting result for the cerebrovascular angle, where BBB dysfunction and glymphatic clearance failure are upstream of plaque accumulation rather than a downstream consequence. The LRP1 transport mechanism and the multivalent ligand design are clever and well-grounded. The fair claim is "we improved amyloid clearance and rescued behavioural deficits in an amyloid-overexpressing mouse by targeting BBB transport." That's a real contribution. "Reversed Alzheimer's" sells the mechanism by overstating what it did, and it sets up the same disappointment cycle the field has been through with every other anti-amyloid intervention that worked great in mice.
Sweet! Is your focus more on home setups with VR rigs, or do you also have any plans to review commercial VR racing places like F1 Arcade or World Of Racing?
Yes, they really should go to prison, for really reals, if they really kill, maim, or otherwise injure another person or damage property.
If they don't hurt or kill anyone, and don't damage property, you might convince me their vehicle and license should be confiscated, and they should be banned from driving for life.
I only made one citation in my comment and the source was the propaganda of the DPRK itself. You may want to check again who you're responding to because you seem confused.
And, even though this is their "best foot forward", it makes the whole country look like what the rest of us would consider a goddamn prison camp. The stories about North Korea are insane, but they are accurate.
but I feel like what the 박연미 types are saying are either exaggerated or false, as the south and US think tanks pays them to come up with the most insane story
Only an idiot would shill for brutal dictatorships like this, ignoring all available evidence in favour of their feelings. Congratulations, you're a Donald Trump voter.
I'm so fucking confused, man. I'm a tech guy. I've spent my whole life getting good with computers, I know very little about cars, and I just can't keep up. I've heard that yeah ethanol is bad but put in your tank what the manual says because if your engine isn't designed for "high-octane" fuel (???) you'll damage your car with the pure stuff? But I know how ethanol dries out rubber, which I'm quite sure is what my fuel lines are made of, but my manual says to use 85. So should I be using 87 and avoiding 85? Or...?
I just want an electric car. "Plug it in", I get.
Edit: Thank you to everyone who responded! It was salient as I was actually driving at the time and saw the comments before my next stop; I ended up getting the right gas thanks to you all. My car immediately started running better. I'm a lot less confused now, I'll be using 87 gas from now on. Thankfully my car seems to have survived my mistake(s) without any immediately negative consequences >.>
Fuck yeah. Who doesn't like good news? 🎉 Also, really surprised they got it working well enough on RDNA 2 to plan to release it, that's just gravy on the cake.
The protests have grown by a million people with every event, give or take. They show the people who have a problem with this shit that they're not alone, and more and more people have a problem with all this. The protests show the people in power right now that we are not going to lay down and take it, like you lot want to keep saying we are.
So if you really want these fuckers gone as badly as the rest of us, how about you take your defeatist crap and keep it at home with you? It's not helping anyone except the fascists.
Or you could stop doing the work of the fascists, but I think you like the kool-aid too much for that. Feels good talking down to people being killed for resisting, does it? You're as bad as the people you claim to hate, you just can't see it.
Don't worry, most people grow into empathy eventually, we all develop at different rates.
Yes, collateral damage is to be expected when a superpower gets destabilised. Why are you ignoring the fact that there was documented election interference on a massive scale? Why are you ignoring the total takeover of our government by hostile actors? Are you trying to paper over all of that for some particular purpose?
Moreover, you're mostly addressing the victims of the fascists here. We're not actually in charge of the country right now.
Personal ones. If I had to distill it here, I require that my prose be varied but sensible (e.g. breaks the rules for readability, never egregiously), with no formula, no waffle words, and no meaningless sentences. Tropes can be fine but only used sparingly, naturally, and absolutely not always in the same place. Reading level should be collegiate, but not doctoral, and industry terms should be defined on first use. These are stylistic questions shaped by years of reading professional authors and no AI has any idea how to do that out of the box. Reading what most people put out with AI, I can see the patterns like repeating textures, and it grates on my optic nerves.
I'm making progress on that with mine, but it's a tough problem. Needs manual tweaking even after multiple rounds of automated revision.