Pay off all your debts, six months of needs liquid in a high yield savings account for your emergency fund. You can save for a house and put the rest in an index fund after matching whatever incentive your job gives for the 401k. Even the best investment firms really don't beat the market in the long-run so I wouldn't suggest getting fancy with your investment strategy. Watch out for dumping your money into a new car or other things that really don't have a return but also make sure to set some money aside to enjoy life. The general rule is 50/30/20, don't exceed 50% on needs, 30% on wants and put at least 20% into savings & investment. That said with your current situation you could build a good base for yourself and do 15/25/60. I'm not sure where you are but assuming the US housing market if you could put away 80K that would be helpful but not necessary.

If you have student loans or really any debt might be a good time to clear it out completely if you want. It's very freeing.