You probably can unleash your special interest again without denying yourself.
I'm not trans (I think), but I do hyperfixate (probably on the spectrum, a shrink even said so but he wasn't abilitated to do an official diagnosis), and I feel like one of the good things about hyperfixations is how they're things outside of yourself, and how you feel about them isn't too affected by how you feel about yourself or your immediate surrounding. I feel if I became a girl, my interest for my hyperfixations, including past ones would be one of the most consistent things about me, I wouldn't feel the need to change or deny them even as I'd change everything else.
Sorry if my experience isn't relevant tho, I may not understand every trans issue.
If you mean as the artist, just work in high resolution in the first place.
If you mean using AI upscaling on someone else's webcomic that's already been shared several times and lost quality along the way before reposting, that's because it can cause aberrations and sometimes looks uglier than a low quality webcomic. Better to reverse-search it with tineye to find the original, which should be in good quality.