History has proven time and again that given the opportunity, the nation's bordering Israel in every direction (save possibly Lebanon) will try to either annex Israel or restore the entirety of it to an Arab nationalist muslim government.
Should such an event come to pass, the displacement of the entire population would be a best case scenario. The Jewish population of Syria and Jordan are both zero, and Egypt's is less than 20, down from several hundred thousand between the three in 1948.
There is no way to interpret the Hama's charter other than incitement to genocide.
The major factors preventing another Arab-Israeli war are tensions with Iran, Billions of dollars in US military aid, and the nuclear weapons likely owned by the Israeli state.
Dissolve the Israeli state, and unless you replace with something similar, and those factors will no longer stand. Compromise the territorial integry of the new state to any serious degree, including ceding the west bank to a Palestinian state, and Israel becomes militarily indefensible.