Given that Starfield has been considered a bit "meh" by many, you have to wonder where Bethesda go from here. NakeyJakey hit the nail on the head with many of his criticisms of Bethesda, and show aside you have to wonder what kind of state ES6 (assuming it's their next game) will be in. Since we don't even have a name, it's probably 3-4 years away, and their engine will feel close to 20 years outdated by then - especially if they continue down the path of adding bloat to their core mechanics.
For Todd Howard, I wonder how long he intends/needs to stay at Bethesda post-acquisition. Most of the press for the Fallout show has been positive, but there's been a lot of snark directed at the press of Todd Howard being a visionary, or Fallout being one of the greatest games of all time.
It feels like the next 4-5 years will be critical for them, especially with more critical eyes on their products.