Doable for personal use yes, but not really in a professional setting.
I wish there was, but there isn't right now, and there won't be until a critical mass is there, which is why I want the EU to put the pressure on organisations to change.
The whole world runs on O365, except you, and then you get an excel from a colleague that does a lot of semi complicated maths to help you with your real job, now will you trust that LibreOffice does a good enough job in converting those macros, especially since it could have real world consequences, or will you just pay for a licence?
Or create a great presentation for your boss in OpenOffic, only for it to look like shit when he presents it to his boss.
Not to mention all application that users Ms office components as backend.
There are tons of examples like this.
I'm an open source/free software guy, but in the business world it's going to take legislation to get anything done I'm afraid.