7mo ago

Chinese doctors treated an end-stage type 2 diabetic patient by implanting islet tissue derived in vitro from his own endoderm stem cells. The patient has been insulin-independent for 33 months.

www.nature.com Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue - Cell Discovery

Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue - Cell Discovery

cross-posted from: https://lemmy.ml/post/15676759

Chinese doctors treated an end-stage type 2 diabetic patient by implanting islet tissue derived in vitro from his own endoderm stem cells. The patient has been insulin-independent for 33 months.

Science @lemmy.ml

Chinese doctors treated an end-stage type 2 diabetic patient by implanting islet tissue derived in vitro from his own endoderm stem cells. The patient has been insulin-independent for 33 months.

www.nature.com /articles/s41421-024-00662-3

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I wanted to see exactly where they transplanted the islet cells, because my understanding was that transplanting them to the pancreas was not really viable for a number of reasons:
percutaneous transhepatic portal vein transplantation
Does this mean they implanted them on the surface of the main vein transporting blood out of the liver?
- The allograft they made was from the patients own pluri-potent stem cells, which developed into a piece of tissue comprised of islet beta cells which produce insulin. They took this tissue, cut open this huge vein that goes into the liver, stitched this tissue into the opening, and closed the patient back up.
- Percutaneous means "through the skin": https://en.m.wikipedia.org/wiki/Percutaneous
  In general, percutaneous refers to the access modality of a medical procedure, whereby a medical device is introduced into a patient's blood vessel via a needle stick.
  
  Okay, through the skin, sure, but what about the other 4 words? They go in through the skin into a blood vessel... to where?
  
  Percutaneous: means "through the skin"
  Transhepatic: means "across the liver"
  Portal vein: a major vein that carries blood from the intestines to the liver
  Transplantation: surgical procedure involving the removal of an organ or tissue from one person (donor) and placing it in another person (recipient)
  Just use LLM these days!
  
  Probably the leg bone, most things connect to it.

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