Yes, they do go on some tangents occasionally. I used to think it a bit strange but have grown to like it. A number of years ago Steve went on this Vitamin D research kick and he compared taking supplements versus sunbathing nude (imagining him doing that is hilarious in its own right) and getting his levels checked after each trial. The discussion on this made me decide to start taking Vitamin D supplements and I feel like that has been a benefit.
The Melatonin thing comes from a different research project Steve did to find the “perfect sleep supplement formula” and he experimented for months with different ingredients to come up with what he contends will help him sleep and help him go back to sleep after nighttime bathroom visits. I tried some of the weird ingredients and it did help, but I didn’t stick with that. Even got my wife to try it. I’ve also discovered some great Sci-if authors from their book reviews.
I think they go on these tangents to keep the show fresh after 15 years. I believe that Security Now is TWIT’s most successful show but I wonder how they are doing overall.