Well thats the thing, generally if I see an acronym and have to ask myself how it would be pronounced as a word, by my rule I just spell it out.
For a great example of this (unrelated to FOSS), look at LGBTQIA+. Even though it's a mouthful to say each letter individually, no one wrestles it into "Leguhbuht'kwia plus", it just doesn't make sense and saying it that way would probably ellicit a dead stare from whoever heard it. Unless it's painfully simple to morph into a word or single syllable, I don't bother.
I'm not trying to say this is the right way, mind you. It's just the way that makes the most sense to me.